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Updated Low Carb Diet Side Effects Long Term Trending . Low-carb diets, especially very low-carb diets, may lead to greater short-term weight loss than do low-fat diets. In the long term, ketosis and carbohydrate deficiency can be dangerous for the body. Low-carb diet safety concerns relate to ketosis, long-term cardiovascular safety, lipid, and renal effects. Research presented Tuesday at the European Society of Cardiology Congress in Germany found that diets. These side-effects will subside once you get into an ongoing low-carb way of eating. Pin on Keto (Mike Collier) The downsides: While the research is exciting, there's very little evidence to show that this type of eating is effective — or safe — over the long term for anything other than epilepsy. In the long term, ketosis and carbohydrate deficiency can be dangerous for the body. Here are some of the problems you may encounter; Dehydration, Leg Cramps, Frequent Urination, Constipation, Irregular Men